?Quality control standardization of Indonesian noni fruit (Morinda citrifolia) extract and evaluation of their angiotensin-converting enzyme inhibitory activity

Morinda citrifolia fruit (Noni) has been used as a folk medicine in several countries. Noni possessed various pharmacological activities such as; anticancer, antidiabetic, antihypertensive, antarthritic, and antioxidants. The present study evaluated pharmacognostic properties, profiling of active constituent through High-Performance Thin Layer Chromatography (HPTLC) Liquid Chromatography-High Resolution Mass Spectrometer (LC-HRMS) run for quantitative qualitative phytochemical analysis determining angiotensin-converting enzyme (ACE) inhibitor activity from three different locations. physicochemical parameters crude drugs extracts met the requirement Indonesian Herbal Pharmacopeia. Total phenol content was 2.16-3.08 mg GAE/g extract total flavonoid 0.11 - 1.58 QE/g extract. HPTLC revealed that scopoletin range 0.44 0.51%. results were also corresponding well with LC-HRMS fingerprint analysis. In addition, Bogor potential exhibited inhibiting ACE an IC50 value 206.26 µg/mL.